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Curcumin also induces epigenetic activation of miR-145, leading to its enhanced transcription [71]

Indeed, based on the recently released EULAR (European League Against Rheumatism) points to consider on PsO to PsA transition, it is possible to identify a phase of psoriasis at higher risk for PsA that is typified by medium- to long-term risk factors (average of 712 years before PsA onset), including severe skin involvement, nail psoriasis, obesity and familial history for PsA, and a phase of subclinical PsA encompassing short-term risk factors (average of 13 years before PsA onset), including arthralgia and imaging evidence of synovio-entheseal inflammation (Fig

Meanwhile, the endogenous neurotrophic factor system, especially its members with high affinity and specificity for midbrain dopaminergic neurons, constitutes an important defense mechanism against neurodegeneration