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In a 12-week study, 33 non-diabetic adults were stratified around the median plasma apoB into a high-apoB (123 mg/dL) group (n = 17) and a healthy-apoB (85 mg/dL) group (n = 16)

In addition to the above epidemiological findings, many pre-clinical laboratory studies have focused on the impact of IGF-1 in cancer cell proliferation, migration, tumor growth and metastasis using in vitro and in vivo models to identify the signaling pathways involved in these processes