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We focus on delineating how this integrated approach moves beyond the limitations of conventional monotherapy, explore the emerging evidence supporting its clinical application, and identify key questions that must be addressed to advance its role in modern, precision-oriented UC management

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In most cases, treatment for B12 deficiency is effective, and a person will not continue to have symptoms

System preparation and explicit molecular dynamics simulation The best poses of the receptor-ligand docked complexes were collected corresponding to the highest negative docking scores and subjected to 100 ns classical molecular dynamics (MD) simulation in an explicit solvent under Linux environment on HP Z2 Microtower workstation using the free academic version of Desmond v5.6 49 module in Maestro-Schrdinger suite 2018-4 50