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Ferroptosis is a distinct form of PCD driven by iron-dependent lipid peroxidation

Nature 467 , 963966 (2010)

This hypermethylation has also been observed in PCa cells [94]

Upon activation, the p38 MAPK signaling pathway induces robust oxidative stress response and triggers the release of a plethora of inflammatory factors, including TNF-, IL-1, and IL-6