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Clinical trials of sermorelin did not include patients with pituitary tumors or other brain lesions causing hormone deficiencies, so safety and efficacy in this group are not established

Proc Natl Acad Sci 94:98669868

YousefzadehMJFloresRRZhuYSchmiechenZCBrooksRWTrussoniCEet al

Importantly, co-treatment with ATP and rotenone resulted in NLRP3-dependent caspase-1 activation whereas rotenone treatment alone had no significant effect [55]