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The deficiency causes a reduction in red blood cell production, which results in anemia and a reduced oxygen supply to tissues and organs

mRNA and protein levels of CLOCK and BMAL1 were down-regulated in insulin-resistant primary mouse hepatocytes [31] and C2C12 myotubes [46], while ectopic expression of CLOCK and BMAL1 proteins increased insulin sensitivity

Distinct microbial taxa are associated with production of BB versus TMA or TMAO from dietary L- carnitine We next sought to test whether the enhancement of BB versus TMA/TMAO production observed from L -carnitine in the chronic L -carnitine supplemented mice indicated enrichment of distinct taxa better suited for either BB versus TMA/TMAO production

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