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Clinical studies on IV glutathione for skin brightening have documented the most dramatic melanin index reductions with this route

Additionally, it is known that COX-2 mediates the development of inflammatory processes in the skin, while administering specific COX-2 inhibitors reduces the levels of inflammatory markers, such as macrophage inflammatory protein 2 (MIP-2) and TNF- in skin with inflammatory hypersensitivity and nociception, as well as decreasing edema and vascular permeability [112]

For reference, the peptide calculator can help with general dosing calculations, though HCG dosing specifically requires understanding the IU (international unit) system rather than milligram measurements used for most peptide dosages

Heliyon 10(5):e27110