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The following MaPPs are specific for NDA applicants: Review of the Same Supplemental Change to More than One NDA or ANDA in More Than One Review Division NDAs and BLAs: Filing Review Issues Action Packages for NDAs and Efficacy Supplements Refusal to Accept Application for Filing From Applicants in Arrears Requesting and Accepting Non-Archivable Electronic Material for CDER Applications Accelerating Compliance Time Getting FDA approval for new pharmaceutical products requires careful recording of compliance of your development processes

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In the apo structure of ICL1, the active site loop (residues 185196) preferentially maintains an open and solvent-accessible conformation [162], where Cys191 is positioned at a considerable distance away from other catalytic residues