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In addition, GSTs may participate in the passive non-catalytic binding of substrates and sequestration, which prevents the binding of xenobiotics to their target proteins [45-48]

Variants like C677T and A1298C can reduce enzyme efficiency, potentially leading to higher homocysteine levels and impacting processes like detoxification, neurotransmitter production, and cardiovascular health

To predict, prevent, and manage post-traumatic stress disorder (PTSD): a review of pathophysiology, treatment, and biomarkers