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MG-induced DNA damage plays a central role in initiating apoptosis.MG induces DNA strand breaks through the formation of adducts (e.g., MGdG) and cross-linking structures with DNA, activating the intracellular DNA damage response, and triggering apoptosis by cell cycle arrest when the damage exceeds the cellular ability to repair it (104)

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In healthy rats, it increased insulin levels by more than 500%, exerting a marked hypoglycemic effect throughout the experiment, while glucose levels returned to baseline despite only increasing insulin by just under 25% in hyperglycemic rats