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The blocking of the cycle by low ATP is more likely associated with a decrease of cysteine bioavailability

5 Enzyme inhibitors are substances which are able to prevent the metabolic action of an enzyme

Distinction with other differential diagnoses is a challenge for clinicians

In summary, the metabolic shift towards glycolysis is a central feature enabling GC B cells to acquire effector functions, produce autoantibodies, and drive SLE pathogenesis, highlighting their potential as targets for metabolic intervention