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10.1161/JAHA.118.008642 94

Karagiannides I, Tchkonia T, Dobson D, Steppan CM, Cummins P, Chan GHH, et al

Melasma and other skin manifestations or oral contraceptives

The molecular mechanism depicted was via activation of Mitogen-activated protein kinase p38 (p38 MAPK) and the E3 ubiquitin ligase Atrogin1/MAFbx, the latter being up-regulated during immobilization also in humans and involved in increased proteasome activity [129]