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doi: 10.1038/nchembio.687 6 MauerJLuoXBlanjoieAJiaoXGrozhikAVPatilDPet al

Who Is a Good Candidate for Infusion Therapy

However, the role of glutamine in continuous cell proliferation as an anabolic substrate is controversial, as its limited availability in tissues and circulation restricts its biological role in this process (Brosnan, 2003

In the context of limited glutamine, various cell components in the TME compete for glutamine, and tumor cells can increase their uptake of glutamine due to their unique metabolic mode, thus providing certain competitive advantages