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5.5 Abnormal Ovarian Enlargement In order to minimize the hazards associated with abnormal ovarian enlargement that may occur with GONAL-f therapy, individualize treatment and use the lowest effective dose [see Dosage and Administration (2.2, 2.3)]

It is possible that genetic deletions affecting a large number of cells may produce more pronounced compensatory effects during development masking the effects induced by the lack of GHR in the entire brain

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SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo