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doi: 10.1007/s10637-016-0388-x 67 ChenSHChanNLHsiehTS

The destructive nature of the damage inflicted by these diseases results in a loss of patient dignity and self-worth and negatively impacts family members and friends

Their cell membranes are rich in polyunsaturated fatty acids (PUFAs) that are highly susceptible to oxidation, and due to the minimal volume of cytoplasm, they lack sufficient intracellular antioxidant enzyme reserves and buffering capacity