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In our study, as the intracellular -GC level was only increased slightly compared with that of original strain W303-1b when F pathway was introduced, we artificially introduced a flexible six-glycine linker between the two enzymes of G pathway as well as P pathway to improve the coupling efficiency by mimicking the native domain fusion of GshF

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Total weekly drug exposure (AUC) is the same, so weight-loss outcomes should be similar over a several-month window

Given the potential differences in fundamental bases for BSC- and GLCM-based outcomes (e.g., bulk properties vs