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Recent advances have identified several key signaling pathways and regulatory proteins, including macrophage polarization induced by hyperglycemia and oxidative stress ( Figure 3 )

Therefore, Content of cysteine or cysteine precursors determines the glutathione level in neurons since neurons are not able to use the cystine but rather rely on the availability of cysteine for their glutathione synthesis [20]

The inclusion criteria were i) fulfilment of the 2007 European Medicine Agency algorithm for AAV, the 2022 revised Chapel Hill Consensus Conference nomenclature of vasculitides, and the 2022 American College of Rheumatology and European Alliance of Associations for Rheumatology classification criteria for MPA, GPA, and EGPA (Handy and Loscalzo, 2022

lncRNA GAS5 regulates the expression of ATG5 and ATG12 through its interaction with miR-181c-5p and miR-1192, thereby promoting autophagy [130]