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However, the evaluation of the prognostic value of IGF-1 serum concentrations as a continuous measure by using restricted cubic splines revealed a nonlinear association with reduced mortality for high IGF-1 levels (p-value 0.01, Fig

As in Supplementary Fig

In order to restore the tissues integrity, not only do resident stem cells have to be activated, but also some differentiated cells must revert to a stem cell-like state and acquire mobility