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However, due to the absence of centrioles, the resultant spindle morphology is reduced in size, and the characteristic astral microtubules at the poles are absent, contributing to the increased instability of spindle assembly in human oocytes

DeSalvo, M

Clin Experimental Neuroimmunol 8:199214 Ali MRA-A, Abo-Youssef AMH, Messiha BAS, Khattab MM (2016) Tempol and Perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress

Further research is needed to fully understand the efficacy and which patients might benefit most