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Similarly, inhibition of SLC7A11 has been shown to sensitise TNBC cells to standard-of-care treatments by impairing glutathione synthesis and redox buffering capacity (108)

Structurally, XO comprises a molybdopterin unit containing an Mo atom

Wachter et al., 2005)

Importantly, the dose of ferrous iron sulfate used in these studies was 0.15 mmol/kg FeSO 4 (human equivalent dose: 1.85 mg/kg), which is less than the recommended dose for an iron supplement (1 tablet with 325 mg FeSO 4 = 5.4 mg/kg)