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Mutations in protein kinase C gamma promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition

The perturbed glutamine-glutamate metabolism induced neurotransmitter imbalance and created an immune-inhibitory state with increased gamma-aminobutyric acid/glutamate ratio, thus facilitating efficient viral replication both in JEV-infected neurons and the brain of JEV-infected mice

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It was demonstrated that the application of antioxidants, i.e., Vitamin C, Vitamin E, and turmeric, greatly increased the circulating levels of T3 and T4, which could be caused by the direct participation of antioxidants on the thyroid gland or the activity of deiodinase enzyme (125)