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Neoangiogenesis and Immune-regulation are Two Fundamental Functions of VEGF VEGF-induced neoangiogenesis is the determining factor of cancer progression As the primary mediator of tumor-angiogenesis, VEGF plays a significant role in tumor growth

Chen L-Y, Kang Y-N, Hoang KD, Chen K-H, Chen C

Mukaremera and Nielsen, 2017)

Alpha-fetoprotein (AFP) is a glycoprotein that is highly expressed in embryonic liver and in hepatic progenitor cells (hepatoblasts) ( in vitro cultured hepatocytes obtain and maintain a mature differentiated state versus a proliferative dedifferentiated phenotype