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No large trials proving combination superiority

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Circ Res (2008) 102:123946

some individuals report sleep disturbances Foods and Substances to Avoid Around Dosing To optimize AOD-9604s effectiveness, avoid the following in the hour before and 30-60 minutes after administration: All foods (proteins, carbohydrates, fats trigger insulin response) Caloric beverages including juice, milk, sports drinks, protein shakes Artificial sweeteners (may trigger minor insulin response in some individuals) Coffee with cream or sugar (black coffee or tea without additives is acceptable) Acceptable During Dosing Window: Water, black coffee, unsweetened tea, electrolyte water (zero-calorie), and medications as prescribed