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Intriguingly, PIK3C3/VPS34 lactylation augments its interaction with Beclin1, Atg14L, and UVRAG, increasing its lipid kinase activity and promoting macroautophagy/autophagy and endolysosomal degradation

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These include the quadriceps group, especially the vastus medialis and vastus lateralis, as well as the hamstrings, gastrocnemius, popliteus, and even the hip muscles such as the gluteus medius and hip adductors

Future studies should aim to dissect the individual roles of aurora kinase inhibition versus PI3K/Akt activation in mediating neuroprotection, employing selective inhibitors or genetic approaches