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The initiation of BBB disruption can be direct, for example, due to an infection, or can be triggered by the activation of neuroinflammatory pathways following brain damage

OT and AVP: The neuropeptide hormones OT and AVP belong to the same superfamily, and genetic variants in OXT , OXTR , arginine vasopressin receptor 1a ( AVPR1a ) and CD38 (lately demonstrated as essentiall for social behaviour because it mediates oxytocin secretion) have been verified to be associated with autism

AEDG is the most extensively characterised of this family in the contemporary international literature

The National Institutes of Health study reports that between 1.5% and 15% of the public has a deficiency