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Combined results of biochemical and histopathological evaluation verified the superiority of surface modification of phytochemical with chitosan coating could be of great value in management of TBI

Cross-linking theory relies on the fact that protein cross linking occurs over time which causes their toxic accumulation and thus results in damage to healthy cells and tissues (Nagy and Nagy, 1980)

Multiple studies, both in North America and Europe, have shown that MTTT has improved sensitivity compared with STTT, without losing specificity [Citation32,Citation33]

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