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Some of the less reactive of these species (such as superoxide) can be converted by oxidoreduction reactions with transition metals or other redox cycling compounds (including quinones) into more aggressive radical species that can cause extensive cellular damage

These findings are supported by additional studies that highlight the association between overly restrictive sodium diets and increased risk of malnutrition [5, 65]

The role of ROS in the occurrence and development of breast cancer The occurrence of breast cancer, the most common malignancy in females worldwide, is generally believed to be significantly associated with the accumulation of genetic damage caused by genetic alterations, which cause uncontrolled cell proliferation and/or abnormal programmed cell death, or apoptosis [60]

J Exp Clin Cancer Res 27(1):34