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The nature of how impaired glutamate cysteine ligase, the enzyme that naturally produces Glyteine, can make cells more susceptible to mutagens due to lower glutathione [4, 5] has been well studied

Next, we demonstrated in T-cell leukemia and lung cancer cell models that NKX2-1 binds and transcriptionally upregulates serine/glycine synthesis enzyme genes including phosphoserine phosphatase ( PSPH ) and serine hydroxymethyltransferase ( SHMT )