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The CoQ10, a safe natural antioxidant, is supported by the lack of adverse effects

Although its extraction method has been mature, the study of its monomer is still in the initial stage, and there is no complete human efficacy and safety evaluation report, which poses a major challenge to the clinical promotion of cynaroside

Clinical evidence demonstrates that oral doses of 13 grams per day, administered for 612 months, can reduce neuropathic pain scores, with enhancements in nerve fiber regeneration and sensory function, particularly when combined with standard therapies [5]

doi: 10.3389/fcimb.2024.1328419 43 De AngelisCNardoneAGarifalosFPivonelloCSansoneAConfortiAet al