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Drugs Under Experimental and Clinical Research 10: 107111, 1984 Garzya G, Amico RM

For patients with uncontrolled hypothyroidism, thyroid hormone replacement should be optimized first, as untreated hypothyroidism can affect glucose metabolism and weight management outcomes

For example, not fully clarified are functions of pleiotropic compounds formed through TRP-KYN pathway, such as kynurenine (KYN), anthranilic acid (ANA), kynurenic acid (KYNA), and quinolinic acid (QA), capable modulate brain and immune system, and which play a role in the pathogenesis of a wide range of illnesses, including cancer, liver cirrhosis, and neurodegenerative and psychiatric diseases, such as dementia, Alzheimers disease, Parkinsons disease, multiple sclerosis, and schizophrenia [2,3]

Malaguarnera, M., Risino, C., Cammalleri, L., Malaguarnera, L., Astuto, M., Vecchio, I., and Rampello, L