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Pairing with Microneedling Microneedling creates temporary micro-channels through the stratum corneum into the dermis

AOD9604 and Cartilage Biology Research In a collagenase-induced knee osteoarthritis rabbit model, intra-articular injection of AOD9604 significantly enhanced cartilage regeneration compared to saline controls, with combined AOD9604 and hyaluronic acid injections proving more effective than either treatment alone producing superior morphological and histopathological scores and a significantly shorter lameness period in the AOD9604 + HA group

They get shots less often, usually once a month

The primary safety concerns include immunogenicity (development of antidrug antibodies), gastrointestinal reactions, and contamination risks in unregulated products