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Such changes could conceivably expose tissues to elevated levels of glucocorticoids and contribute to the aging process

doi:10.3390/ijms18010200 Hell R, Bergmann L (1990) -glutamylcysteine synthetase in higher plants: catalytic properties and subcellular localization

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The accumulation of ceramide in the intestine disrupts hepatic lipid regulation via the gutliver axis, resulting in lipid deposition and metabolic disorders [26]