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PMID: 37680473 iScienceTOPK mediates immune evasion of renal cell carcinoma via upregulating the expression of PD-L1

Elevated circulating IL-6 is consistently observed in both cancer patients with weight loss and in animal models of cachexia, where it drives muscle atrophy, adipose tissue depletion, and systemic metabolic derangement [8,9,10]

We detected higher oxidized states of Cys 170 of phosphofructokinase (PFK), Cys 247 of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Cys 379/80 of phosphoglycerate kinase (PGK) and Cys 49 and Cys 326 of pyruvate kinase M (PKM), which were all reported to interfere with either the primary or secondary function of these enzymes 32,33,34,35