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The defect involves pH-dependent TRPML1-mediated efflux of calcium that activates c-Jun amino-terminal kinase ( JNK)-mediated phosphorylation of dynein intermediate chains, and thereby impedes retrograde motility 19

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[0319] As indicated above, in various embodiments, the antibody binds (e.g., specifically binds ALPP and/or ALPPL2 (see, e.g., Fig 1 for ALPP and ALPPL2 sequences)

Prolin | nicht-essentiell: Die Aminosure wird aus Glutaminsure hergestellt, doch im Alter und bei chronischen Erkrankungen reicht die Prolin-Synthese meist nicht aus