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In addition to in situ effects on bone tissue, some natural or engineered EVs also participated in gut microecology in the anti-osteoporotic process, suggesting the involvement of the gutbone axis

In clinical practice, lifestyle modifications and hypoglycemic drugs are commonly used to manage DM

Mitochondrial oxidative phosphorylation, essential for neuronal energy production, also generates reactive oxygen species (ROS), which increase with age and contribute to oxidative stress