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Figure 3C (inset) shows that ADPR production in LP-1 cells increases consistently following anti-CD38 antibody treatment: mean ADPR peak areas rose from 9.56 2.00 in the IgG1 control to 11.47 1.60 with DARA and 12.42 1.80 with ISA

The stopper material can become brittle at sub-zero temperatures and may not reseal properly after thawing

This is more problematic with methadone, given its steeper dose-response curve as compared to buprenorphine and lack of ceiling effect on respiratory suppression