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In some examples, a single modification, such as a single substitution or replacement of amino acid, alters 2, 3, 4 or more properties or activities of an FX polypeptide

Nose-to-brain administration is an innovative drug delivery technique designed to bypass the BBB and directly administer medication to the brain, utilizing either nanoemulgel for enhanced glioblastoma treatment [30, 31] or chitosan (CS) formulations for schizophrenia management [32]

Given the limited availability and heterogeneity of this tissue, developing a standardized and unlimited cell source with high efficacy and safety would greatly assist in the commercialization efforts of ESC-based SCTs

Moreover, our ICU often accepts severely ill patients as our ICUs are located at tertiary academic hospital