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Description

The applicant asserted that for these reasons TERLIVAZ offers a treatment option for HRS patients unresponsive to currently available treatments (for example, norepinephrine, midodrine, ( and octreotide), and it significantly improves clinical outcomes among HRS patients as compared to placebo as well as currently available treatments (for example, norepinephrine, midodrine and octreotide)

This process can occur directly through extracellular vesicles (EVs), short-chain fatty acids (SCFAs), polyamines, and hydrogen sulfide or indirectly by interacting with immune cells or hormones (126)