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When a deficiency in glutathione develops, glutathione obtained from the diet does not offer an answer because the absorption in the gut is extremely poor

Homocysteine, a risk factor for cardiovascular disease, interferes with the translational reading of SECIS in the expression of GPx1 [53] and, therefore, inhibits the expression of GPx1 promoting the increase of oxygen species reagents that inactivate nitric oxide and cause endothelial dysfunction

The ratio of the two forms to each other in a cell determines the status of redox reactions (chemical reactions in which one reactant transfers electrons to another reactant) in the cell

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