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At the same time, we also face many challenges: the development of novel ferroptosis-inducing drugs requires consideration of drug toxicity and prevention of off-target effects to avoid other adverse reactions in patients

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Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y (2009) Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy