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Nau R, Srgel F, Eiffert H (2010) Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections

For example, the inhibition of histone deacetylases or demethylases interferes with the chromatin modifications that maintain DTP cells in a drug-tolerant state, such as the retention of closed or repressed chromatin at pro-apoptotic loci, thereby restoring susceptibility to drug-induced apoptosis (55)

An animal is considered to be in the open area when all four paws are in an open quadrant and in the closed area only when all four paws have crossed from the open to the closed boundary

The primers used for the construct preparation are listed in Table S1