glutathione increases in cancer cells is critical for NK cell-mediated immunity A study shows that the

Similarly, in T cell-driven graft-versus-host disease (GVHD), FXR agonism exacerbated mortality, while T cell-specific FXR deletion or UDCA administration (again exhibiting FXR antagonistic properties) improved outcomes ( 3.1.2 Takeda G protein-coupled receptor 5 modulators: harnessing biased agonism TGR5, predominantly activated by secondary BAs like lithocholic acid (LCA) and DCA, exerts immunomodulatory effects ( 3.1.3 Therapeutic utility of specific bile acids: UDCA/TUDCA and emerging candidates Beyond their roles as ligands for specific BARRs, certain BAs themselves are used or being investigated as therapeutic agents due to their pleiotropic effects

Ahmed MN, Zhang Y, Codipilly C, Zaghloul N, Patel D, Wolin M, Miller EJ (2012) Extracellular superoxide dismutase overexpression can reverse the course of hypoxia-induced pulmonary hypertension

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