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The investigators showed that there were no reported toxicities, and supplementing with selenium did not decrease the efficacy of radiation treatment (61)

2 An overview of the cGAS-STING signaling pathway The cGAS-STING signaling pathway is widely distributed in immune cells, non-immune cells, tumor cells, and other tissue-derived cells (1315)

Updated November 14, 2024

A possible explanation for these studies is that alterations in SCFA content in AS patients lead to impaired Treg function, which results in activation of the IL23-IL17/22 axis and dysregulation of mucosal cells involved in type 3 immunity and regulated by RORt (e.g., ILC3, invariant natural killer T (iNKT) cells, MAIT cells, and -T cells) (147)