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289 Transdifferentiation of VSMCs into macrophage-like cells plays a role in vascular hyperplasia and atherosclerosis during chronic inflammation

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This is achieved by specifically modulating the GM to increase the abundance of Muribaculaceae, Alloprevotella, and Parasutterella, which enhances SCFAs production, elevates serum GLP-1 levels, and reduces GRP43 in the ileum