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Recently, new efforts have been made to design molecular constructs that mimic or replace co-chaperones, thereby increasing HSP70 activity (Zhang et al., 2025)

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Leveraging genetic and epigenetic data holds great promise for the development of precision medicine strategies in the context of mitochondrial dysfunction [33, 34]

Disclosures: Raghav Bassi: Nothing to Disclose, Zubair Bodla: Nothing to Disclose, Mariam Hashmi: Nothing to Disclose, Fatima Niaz: Nothing to Disclose, Muhammad Khalil: Nothing to Disclose, Yaseen Perbtani: Nothing to Disclose, Tony Brar: Nothing to Disclose 1676 ACTIVITY METRICS MEASURED BY WEARABLE TECHNOLOGY CORRELATES WITH PATIENT-REPORTED WELLBEING IN CIRRHOSIS Brian McSteen 1 Jessica Siguencia 1 Russell Rosenblatt 2 Arun Jesudian 2 Ana Krieger 2 Avesh Thuluvath 3 Robert Schwartz 4 Robert Brown 2 Adam Buckholz 5 , 1 NewYork-Presbyterian, Weill Cornell Campus, 2 Weill Cornell Medicine, 3 Northwestern University Feinberg School of Medicine, 4 Weill Cornell Medical College, 5 New York Presbyterian Hospital Program Background: Inactivity is associated with progressive sarcopenia, worse transplant outcomes and increased mortality in cirrhosis