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HA, a major ECM component, is elevated in both hypothyroidism and advanced liver fibrosis and has emerged as a potential noninvasive biomarker of disease severity (111)

Injection of adeno-associated virus (AAV)-expressed human a-synuclein in the mouse midbrain induces neuropathological lesions in nigral DA neurons, including increased a-synuclein inclusions and progressive axonal degeneration [31]