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In LSDs, defective enzymes lead to the accumulation of toxic substances in the lysosomes, causing cell damage and degeneration of neural tissue

[DOI] [PubMed] [Google Scholar] Riley 2011 Riley RD, Higgins JP, Deeks JJ

PLoS Computational Biology , 14 (1), e1005968

For instance, oral administration might be subject to first-pass metabolism in the liver, reducing the effective concentration of 5-Amino-1MQ compared to a direct subcutaneous injection