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Up to 29% of cases recur within five years after primary surgery, and only one third of CRC diagnoses are localized at the time of detection ( The persistently low survival rates and high recurrence of CRC can be attributed to cancers ability to develop resistance against existing therapies ( 2 Mechanisms of chemotherapy resistance in CRC 2.1 Resistance due to modulation of cell death pathways 2.1.1 Evasion of apoptosis Apoptosis is a natural process of programmed cell death, allowing for the regulation of homeostasis through the maintenance of normal cells and embryonic development ( p53 is a crucial tumor suppressor that responds to a variety of stress signals, including DNA damage and oncogene activation

10.1093/jpp/rgad097 237

Shafique, K., McLoone, P., Qureshi, K., Leung, H., Hart, C

The length of gene and coding DNA sequence vary from 333 bp ( SlGSTU 57) to 6206 bp ( SlGSTZ 1) and 237 bp ( SlGSTU 41) to 1245 bp ( SlEF1B 3), respectively