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These factors are important to consider in the quest to enhance antiaging influences and expand the healthspan of humans in the future [9, 16]

Understanding these mechanisms provides the foundation for exploring therapeutic interventions that might support cellular health throughout the aging process

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[140] [141] [142] [143] For example, leptin can be found in the synovial fluid in correlation with the body mass index, and the leptin receptors are expressed in the cartilage, where leptin mediates and modulates many inflammatory responses that can damage cartilage and other joint tissues