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101 As a selective autophagy receptor, p62/SQSTM1, when upregulated in nematodes and Drosophila , can promote protein homeostasis and extend lifespan

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Concerning histone modifications, granulosa cells from PCOS patients exhibit enhanced histone deacetylase (HDAC) activity, which decreases acetylation levels of pro-inflammatory cytokines ( e.g ., TNF-, IL-6) and suppresses their transcriptional activation